Tubular chambers have been designed to allow developing cell cultures on cylindrical scaffolds mimicking the effect of flow caused by, e.g., by the blood flow on arteries and veins. Thus, vascular scaffolds are good candidates to be used with this type of chambers, although any other tube-shaped scaffolds or organs can be also cultured in this chambers (trachea, esophagus, etc.).
These chambers allow the user to create two independent flow circuits. The internal or luminal one is intended to circulate culture media through the lumen of the scaffold in order to simulate, e.g., the blood flow circulation, whereas the other one allows the user to circulate culture media around the external surface of the scaffold. Both circuits are not independent and are not connected to each other, which makes possible to use different culture media in both circuits. Co-culture experiments with different media types can be easily performed with these chambers.
Tubular chambers can be adapted to be used with to different scaffold sized both in diameter and in length in order to adapt to different scaffold geometries and sizes. All the chambers can be used in combination with the TEB series to create the desired flow conditions.